Immunohistochemical Profiling of Germ Cells Within the Human Fetal Testis: Identification of Three Subpopulations

FGF9 promotes survival of germ cells in the fetal testis.

In addition to its role in somatic cell development in the testis, our data have revealed a role for Fgf9 in XY germ cell survival. In Fgf9-null mice, germ cells in the XY gonad decline in numbers after 11.5 days post coitum (dpc), while germ cell numbers in XX gonads are unaffected. We present evidence that germ cells resident in the XY gonad become dependent on FGF9 signaling between 10.5 dpc...

The Viability of Human Testis-Derived Cells on Human Serum Albumin-Based Scaffold as An Artificial Male Germ Cell Niche

Azoospermia is one of the challenging disorders affecting couples who are afflicted with infertility. Human testisderivedcells (hTCs) are suitable candidates for the initiation of in-vitro spermatogenesis for these types of patients.The current study aimed to assess the proliferation of hTCs through the cell culture on the three-dimensional (3D) porousscaffolds. Cells harveste...

O-3: Identification and Characterization of Repopulating Spermatogonial Stem Cells from The Adult Human Testis

Background: This study was conducted to identify and characterize repopulating spermatogonial stem cells (SSCs) in the adult human testes. Materials and Methods: Testes biopsies from obstructive azoospermic patients and normal segments of human testicular tissue were used. Flow cytometry, real time PCR and immunohistochemical analysis were performed. Purified human spermatogonia were transplant...

Subpopulations in Human Obesity Profiling of the Three Circulating Monocyte

histological evaluation of the effect of three medicaments; trichloracetic acid, formocresol and mineral trioxide aggregate on pulpotomized teeth of dogs

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